Abstract: Based on the general nature of "matter" and "significance" of manuscript as a document, the value and limit of manuscript in academic research are discussed. The general "revealing of the voice" of the manuscript does not rule out that some authors intend to use this to create a secret "posturing" of "sincerity". Even if the script is written straight out of the heart, there is also the connection and difference between the truth of knowledge, the truth of thought, and the truth of reality. Combined with the complexity of "facts", researchers are required to at least have the ability to change lines at any time to see the personnel, ideas, art and literature in history from the perspective of the authors behind different documents. Therefore, those who make good use of manuscripts must be able to look at all kinds of documents containing manuscripts from an equal perspective, appropriately locate the relevant facts and levels of each place, and see "things" as "significance" according to the "text", fully reflecting the appropriate value of manuscripts in academic research.