Abstract: Quine responded to the question of ontological relativity raised by traditional epistemology from the perspective of multi-type evolution of scientific knowledge and language expression. Quine regards scientific knowledge as a system that is constantly being falsified and revised by experience, thus confirming that ontology can only manifest its theoretical significance relative to a specific knowledge background. Quine's holism theory of knowledge builds a system of scientific knowledge based on the principle of "convenience to use", and filters and selects some knowledge that meets the reasonable needs of ontological relativity. As a result, scientific knowledge can be modified and each part of knowledge incomparable conflict. The essence of Quine's verification strategy is to use the relativity of epistemology to defend the relativity of ontology, which leads him to fall into the abyss of narrow relativism, and his ontology's discussion of "what exists" also falls into the rut of empty promises.