Abstract: State-level new areas are new regional organizations and comprehensive functional platforms built on the city-region scale. State-level new areas cooperation has become a new model for achieving cross-regional collaborative innovation and development. The article takes spatial production as a key perspective to understand cross-regional collaborative innovation cooperation in state-level new areas, based on the study of typical cases of collaborative innovation cooperation in Chongqing Liangjiang state-level new area and Sichuan Tianfu state-level new area, the findings show that collaborative innovation cooperation in state-level new areas is rooted in the political, economic, institutional and social environment of the region, and is inseparable from the integration function of spatial production factors such as power, capital, policy, and social network, and has gone through three spatial integration stages: weak connection, intermediary connection, and strong connection. Among them, power reconstruction is the core driving force of spatial production, capital de-regionalization is the forerunner of spatial production, policy boundary weakening is an important institutional foundation for spatial production, and collaborative networks play an important connecting role.