Abstract: Under the background that the trade war between China and the United States has not ended, the spread of COVID-19 has not only inflicted enormous damage on the global economy, but also further affected the development of Sino-US economic and trade relations. Differences in attitudes and means between China and the United States to deal with the epidemic have exacerbated the two countries' conflicts in the ideological field. In the context of the US attempting to curb China's economic and technological development and prevent itself from being overtaken by China, the "Sino-US decoupling theory" in the United States has become rampant again, which will do great harm to the healthy development of Sino-US economic and trade relations. COVID-19 has intensified the strategic competition between China and the United States, and sharply increased the risk of their economic "decoupling". But meanwhile, China's confidence in the strategic game has been enhanced by its effective control of the epidemic. China needs to enhance communication and cooperation with the United States while strengthening its own strength, so as to find a way for great powers with different social systems and ideologies to peacefully coexist, competitively cooperate and achieve mutual benefit.