Abstract: In the context of high-quality development, one of the difficult problems in school-enterprise collaborative parenting is the effective coordination of multiple interests in order-based talent cultivation. Based on the empirical data of 18 order-based classes in technical college, this study develops the "Five-stage, four-subject" model of mixed order-based training. The core stakeholders in practice include technical colleges, teachers, employers, and students in order classes. The interest conflicts and struggling strategies among the stakeholders lead to six forms of conflict of interest. The underlying factors include three aspects, including: the function of macro and micro system being missing and the execution is invalid; the legal status of education by school-enterprise cooperation order being vague; and the cultural concept being conflict and the divergence. In order to effectively coordinate multi-interests and promote the realization of benign struggle, it is important to start with system construction and cultural integration, which include the whole chain optimization management strategy of talent cultivation throughout the five training stages (preparation stage; class organization; class teaching; final assessment; internship employment).