Abstract: The initiation and development of Guangdong-Hong Kong-Macau Greater Bay Area bring both opportunities and challenges to Macau's higher education. At present, Macau's higher education is facing many challenges such as the consolidation of orientation, the limitations of endogenous nature, the lag of legal system construction as well as the imbalance between quality and quantity. In the context of constructing the Greater Bay Area, Macau's higher education should grasp the development opportunities, make rational use of high-quality resources within the area and actively carry out complementary cooperation and benign competition with the universities in the area, so as to switch the challenges into new opportunities. In the process, Macau's higher education needs to get rid of passiveness and take the initiative, take advantage of its strengths to develop with the universities in the Greater Bay Area in complementary ways on the basis of establishing its long-term development plans, and build the brand by continuously improving the relevant institutions or systems and the quality.