Abstract: Faced with the increasingly complex and changeable internal and external economic environment and undergoing the process of accelerating the construction of a new development pattern, the importance of enhancing urban economic resilience driven by innovation has become more and more obvious. Based on the city-level WIPO patent data, an empirical study of the impact mechanism of innovation networks on urban economic resilience finds that the formation of innovation networks in the Guangdong-Hong Kong-Macao Greater Bay Area, especially the joint innovation network, is conducive to the improvement of urban economic resilience. In order to ensure the continuous and stable progress of joint innovation activities and help the construction of resilient cities, it is recommended to build a joint innovation network with "core and periphery", "points promoting surface", and clear levels. Core cities such as Hong Kong, Shenzhen, and Guangzhou should strengthen connections and play a leading role, especially in high-tech fields such as digital economy. Periphery cities need to actively seek cooperation with cities at the same level and participate in high-tech innovation led by core cities.